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KMID : 0359920110300060593
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Korean Journal of Nephrology
2011 Volume.30 No. 6 p.593 ~ p.600
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Urinary Angiotensinogen Excretion and Intrarenal Angiotensinogen Expression in Minimal Change Disease Patients
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Jang Hye-Ryoun
Jo A-Jin
Lee Jung-Eun
Huh Woo-Seong
Kim Dae-Joong
Oh Ha-Young
Kim Yoon-Goo
Park Ji-Hyeon
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Abstract
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Purpose: Urinary angiotensinogen (AGT) has been reported as an important marker reflecting the activity of intrarenal renin-angiotensin system (RAS) in chronic glomerulonephritis patients. We investigated urinary AGT excretion and intrarenal AGT expression in patients with minimal change disease (MCD).
Methods: In 20 patients with biopsy-proven MCD, urinary and plasma AGT was measured using a sandwich ELISA and intrarenal AGT expression was measured with immunohistochemistry. Urine samples from normal healthy volunteers and patients with biopsy-proven thin basement membrane disease (TBM) were used as control groups.
Results: MCD patients showed a wide range of natural logarithm of the urinary AGT/creatinine [ln (urinary AGT/Cr)] and the ln (urinary AGT/Cr) was higher in MCD patients compared with normal controls and TBM controls (normal control vs. TBM vs. MCD, 1.2±0.25 vs. 0.9±0.34 vs. 3.2±0.40). Intrarenal AGT expression was diverse in MCD patients (intrarenal AGT, arbitrary unit, 27.39-78.52 in TBM, 0.00-145.80 in MCD). Ln (urinary AGT/Cr) did not show a direct correlation with intrarenal AGT expression, plasma AGT, or urinary protein/creatinine ratio.
Conclusion: Urinary AGT excretion and intrarenal AGT expression are enhanced in some MCD patients, suggesting that intrarenal RAS is activated in these patients.
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KEYWORD
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Angiotensinogen, Intra-renal RAS, Minimal change disease, Proteinuria
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